Anti-Hu CD193 Purified

Anti-Hu CD193 Purified

• Background: CD193 / CCR3 is a G-protein coupled receptor for several chemokines, namely CCL11 (eotaxin), CCL26 (eotaxin-3), CCL7 (MCP-4), or CCL5 (RANTES). It is highly expressed on eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. CD193 is the key eosinophil chemokine receptor responsible for regulation of eosinophil migration and function. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1.
• Specifications: The mouse monoclonal antibody 5E8 recognizes an extracellular epitope of CD193 (chemokine receptor 3), an approximately 41 kDa protein expressed above all in eosinophils and basophils.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Human
• Immunogen: human CD193 transfectants
• Target Antigen: CD193
• Isotype: IgG2b κ
• Clone: 5E8
• Applications: Flow cytometry: Recommended dilution: 1-4 μg/mL.
• Validated Applications: FC
• Concentration: 1 mg/mL
• Format: Purified
• Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• References & Citations: *Morshed M, Hlushchuk R, Simon D, Walls AF, Obata-Ninomiya K, Karasuyama H, Djonov V, Eggel A, Kaufmann T, Simon HU, Yousefi S: NADPH oxidase-independent formation of extracellular DNA traps by basophils. J Immunol. 2014 Jun 1192(11):5314-23., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=morshed+m+hlushchuk+r+simon+d,
• Storage Conditions: Store at 2-8°C. Do not freeze.