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Anti-SCIMP Purified

CAT: 0270-11-704-C100Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0270-11-704-C100Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II) . There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.
Certification
RUO
Reactivity
Human
Immunogen
Recombinant intracellular part of human SCIMP
Target Antigen
SCIMP
Clone
NVL-07
Applications
FC-IC, IP, ICC, WB (QC tested)
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Draber P, Vonkova I, Stepanek O, Hrdinka M, Kucova M, Skopcova T, Otahal P, Angelisova P, Horejsi V, Yeung M, Weiss A, Brdicka T: SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling. Mol Cell Biol. 2011 Nov;31 (22) :4550-62., URL: https://pubmed.ncbi.nlm.nih.gov/21930792/
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The mouse monoclonal antibody NVL-07 recognizes intracellular part of human transmembrane adaptor SCIMP. This protein of 17 kDa predicted Mw migrates as a 22 kDa band on SDS PAGE.
Applications Notes
Flow cytometry: Recommended dilution: 1-5 μg/ml. Intracellular staining.Western blotting: Recommended dilution: 1-2 μg/ml.
Isotype
Mouse IgG2a

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