Anti-Ms CD18 Purified

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MBS1800937-01	Anti-Ms CD18 FITC
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CAT:

270-11-623-C100

Size:

0.1 mg

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Anti-Ms CD18 Purified

Background: CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1 severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.
Specifications: The rat monoclonal antibody M18/2 recognizes an extracellular epitope of CD18 antigen (integrin beta2 subunit beta2 integrin), a 95 kDa type I transmembrane protein expressed on all leukocytes.
Certification: RUO
Host: Rat
Species Reactivity: Mouse
Negative Species: Dog
Immunogen: Murine cytotoxic T cell glycoproteins
Target Antigen: CD18
Isotype: IgG2a
Clone: M18/2
Applications: Flow cytometry: Recommended dilution: 1 μg/mL.
Validated Applications: FC, IP, WB, IHC-P, IHC-F
Concentration: 1 mg/mL
Format: Purified
Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Cullere X, Lauterbach M, Tsuboi N, Mayadas TN: Neutrophil-selective CD18 silencing using RNA interference in vivo. Blood. 2008 Apr 1111(7):3591-8., URL: https://www.ncbi.nlm.nih.gov/pubmed/18216298?itool,*Abraham C, Miller J: Molecular mechanisms of IL-2 gene regulation following costimulation through LFA-1. J Immunol. 2001 Nov 1167(9):5193-201., URL: https://www.ncbi.nlm.nih.gov/pubmed/11673532?itool,*Barlow SC, Langston W, Matthews KM, Chidlow JH Jr, Kevil CG: CD18 deficiency protects against multiple low-dose streptozotocin-induced diabetes. Am J Pathol. 2004 Dec165(6):1849-52., URL: https://www.ncbi.nlm.nih.gov/pubmed/15579429?itool,*Varga G, Balkow S, Wild MK, Stadtbaeumer A, Krummen M, Rothoeft T, Higuchi T, Beissert S, Wethmar K, Scharffetter-Kochanek K, Vestweber D, Grabbe S: Active MAC-1 (CD11b/CD18) on DCs inhibits full T-cell activation. Blood. 2007 Jan 15109(2):661-9., URL: https://www.ncbi.nlm.nih.gov/pubmed/17003381?itool,*Sanchez-Madrid F, Simon P, Thompson S, Springer TA: Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1. J Exp Med. 1983 Aug 1158(2):586-602., URL: https://www.ncbi.nlm.nih.gov/pubmed/6193226?itool=,*Blocking lymphoma invasiveness with a monoclonal antibody directed against the beta-chain of the leukocyte adhesion molecule (CD18). J Immunol. 1993 May 15150(10):4466-77., URL: https://www.ncbi.nlm.nih.gov/pubmed/8097756?itool=,*Zahálka MA, Naor D: Beta 2-integrin dependent aggregate formation between LB T cell lymphoma and spleen cells: assessment of correlation with spleen invasiveness. Int Immunol. 1994 Jun6(6):917-24., URL: https://www.ncbi.nlm.nih.gov/pubmed/7522049?itool=,*Watts GM, Beurskens FJ, Martin Padura, Ballantyne CM, Klickstein LB, Brenner MB, Lee DM: Manifestations of inflammatory arthritis are critically dependent on LFA-1. J Immunol. 2005 Mar 15174(6):3668-75., URL: https://www.ncbi.nlm.nih.gov/pubmed/15749905?itool,*Avni O, Pur Z, Yefenof E, Baniyash M: Complement receptor 3 of macrophages is associated with galectin-1-like protein. J Immunol. 1998 Jun 15160(12):6151-8., URL: https://www.ncbi.nlm.nih.gov/pubmed/9637533?itool=,*Sakurai E, Taguchi H, Anand A, Ambati BK, Gragoudas ES, Miller JW, Adamis AP, Ambati J: Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci. 2003 Jun44(6):2743-9., URL: https://www.ncbi.nlm.nih.gov/pubmed/12766082?itool,
Storage Conditions: Store at 2-8°C. Do not freeze.

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11-623-C100	Anti-Ms CD18 Purified
12-623-C100	Anti-Ms CD18 Purified Low Endotoxin
1F-623-C100	Anti-Ms CD18 FITC
11-216-C025	Anti-Hu CD18 Purified
11-340-C025	Anti-Hu CD18 Purified
11-216-C100	Anti-Hu CD18 Purified
11-340-C100	Anti-Hu CD18 Purified
11-355-C100	Anti-Bov CD18 Purified
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