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Anti-CRP Purified

CAT: 0270-11-537-C100Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0270-11-537-C100Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The C-reactive protein (CRP) is a cyclic pentameric pentraxin family acute phase protein composed of five identical noncovalently bound nonglycosylated subunits (each subunit 24 kDa; physiologic CRP molecule 117,5 kDa) . CRP is produced by the liver and its plasma levels rise dramatically during inflammatory processes occuring in the body. CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.) and is also believed to play an important role in innate immunity. Patients with elevated basal levels of CRP are at increased risk for hypertension and cardiovascular disease.
Certification
RUO
Reactivity
Human
Immunogen
Purified human CRP
Target Antigen
CRP
Clone
C2
Applications
ELISA, IHC-P
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Meyer MH, Hartmann M, Krause HJ, Blankenstein G, Mueller-Chorus B, Oster J, Miethe P, Keusgen M: CRP determination based on a novel magnetic biosensor. Biosens Bioelectron. 2007 Jan 15;22 (6) :973-9., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=hartmann+m+blankenstein, *Quardokus EM, Saunders DC, McDonough E, Hickey JW, Werlein C, Surrette C, Rajbhandari P, Martinez Casals A, Tian H, Lowery L, Neumann EK, Björklund F, Neelakantan TV, Croteau J, Wiblin AE, Fisher J, Livengood AJ, Dowell KG, Silverstein JC, Spraggins JM, Pryhuber GS, Deutsch G, Ginty F, Nolan GP, Melov S, Jonigk D, Caldwell MA, Vlachos IS, Mueller W, Gehlenborg N, Stockwell BR, Lundberg E, Snyder MP, Germain RN, Camarillo JM, Kelleher NL, Börner K, Radtke AJ: Organ mapping antibody panels: a community resource for standardized multiplexed tissue imaging. Nat Methods 2023 Aug;20 (8) :1174-1178. doi: 10.1038/s41592-023-01846-7., URL: https://pubmed.ncbi.nlm.nih.gov/37468619/
Other References
*van der Harst P, Voors AA, Volbeda M, Buikema H, van Veldhuisen DJ, van Gilst WH: Usefulness of preoperative C-reactive protein and soluble intercellular adhesion molecule-1 level for predicting future cardiovascular events after coronary artery bypass grafting. Am J Cardiol. 2006 Jun 15;97 (12) :1697-701., URL: https://pubmed.ncbi.nlm.nih.gov/16765116/, *Meyer MH, Hartmann M, Krause HJ, Blankenstein G, Mueller-Chorus B, Oster J, Miethe P, Keusgen M: CRP determination based on a novel magnetic biosensor. Biosens Bioelectron. 2007 Jan 15;22 (6) :973-9., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=hartmann+m+blankenstein
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The mouse monoclonal antibody C2 recognizes human CRP, an 117 kDa plasma acute phase protein; it recognizes the antigen both in the presence and in the absence (samples containing EDTA) of Ca2+.
Applications Notes
ELISA: The antibody C2 has been tested as the capture antibody in a sandwich ELISA for analysis of human CRP.
Isotype
Mouse IgG1

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