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Anti-NTAL Purified

CAT: 0270-11-486-C100Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0270-11-486-C100Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NTAL (non-T cell activation linker), also known as LAB (linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
Certification
RUO
Negative Species
Human
Reactivity
Mouse
Immunogen
Recombinant N-terminal cytoplasmic domain (aa 124-203) of mouse NTAL.
Target Antigen
NTAL
Clone
PAb (486)
Applications
WB
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Volná P, Lebduška P, Dráberová L, Šímová S, Heneberg P, Boubelík M, Bugajev V, Malissen B, Wilson BS, Horejsí V, Malissen M, Dráber P: Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. J Exp Med. 2004 Oct 18;200 (8) :1001-13., URL: https://pubmed.ncbi.nlm.nih.gov/15477348/
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The polyclonal antibody recognizes N-terminal cytoplasmic domain of mouse Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 25 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells.
Applications Notes
Western blotting: Recommended dilution: 1 μg/ml; positive control: murine spleen; non-reducing conditions.
Isotype
Rabbit polyclonal

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