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Anti-Thyroglobulin Purified

CAT: 0270-11-466-C100Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0270-11-466-C100Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thyroid disorders are often associated with autoimmune diseases and thyroid cancer.
Certification
RUO
Reactivity
Human
Immunogen
Thyroid follicular cells
Target Antigen
Thyroglobulin
Clone
2H11
Applications
IHC-P
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Magro G, Perissinotto D, Schiappacassi M, Goletz S, Otto A, Müller EC, Bisceglia M, Brown G, Ellis T, Grasso S, Colombatti A, Perris R: Proteomic and postproteomic characterization of keratan sulfate-glycanated isoforms of thyroglobulin and transferrin uniquely elaborated by papillary thyroid carcinomas. Am J Pathol. 2003 Jul;163 (1) :183-96., URL: http://www.ncbi.nlm.nih.gov/pubmed/12819023
Other References
*Lazar V, Bidart JM, Caillou B, Mahe C, Lacroix L, Filetti S, Schlumberger M: Expression of the Na+/I- symporter gene in human thyroid tumors: a comparison study with other thyroid-specific genes. J Clin Endocrinol Metab. 1999 Sep;84 (9) :3228-34. , URL: https://www.ncbi.nlm.nih.gov/pubmed/10487692?dopt=, *Emerson CH, Torres MS: Recombinant human thyroid-stimulating hormone: pharmacology, clinical applications and potential uses. BioDrugs. 2003;17 (1) :19-38. Review., URL: https://www.ncbi.nlm.nih.gov/pubmed/12534318?dopt=, *Hishinuma A, Takamatsu J, Ohyama Y, Yokozawa T, Kanno Y, Kuma K, Yoshida S, Matsuura N, Ieiri T: Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter. J Clin Endocrinol Metab. 1999 Apr;84 (4) :1438-44., URL: https://www.ncbi.nlm.nih.gov/pubmed/10199792?dopt=
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The antibody 2H11 recognizes thyroglobulin (TG), a 610 kDa extracellular secreted glycoprotein specific to the thyroid gland. TG is mainly expressed on thyroid follicular cells (99,1 %) .
Applications Notes
Immunohistochemistry (paraffin sections) : Recommended dilution: 1:80 - 1:100; pretreatment: heat retrieval in 0.01M citrate buffer, pH 6 (microwave oven) ; positive tissue: thyroid gland, follicular adenoma.
Isotype
Mouse IgG1

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