Anti-Thyroglobulin Purified

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CAT:

270-11-466-C100

Size:

0.1 mg

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Anti-Thyroglobulin Purified

Background: Thyroid disorders are often associated with autoimmune diseases and thyroid cancer.
Specifications: The antibody 2H11 recognizes thyroglobulin (TG), a 610 kDa extracellular secreted glycoprotein specific to the thyroid gland. TG is mainly expressed on thyroid follicular cells (99,1 %).
Certification: RUO
Host: Mouse
Species Reactivity: Human
Immunogen: thyroid follicular cells
Target Antigen: Thyroglobulin
Isotype: IgG1
Clone: 2H11
Applications: Immunohistochemistry (paraffin sections): Recommended dilution: 1:80 - 1:100 pretreatment: heat retrieval in 0.01M citrate buffer, pH 6 (microwave oven) positive tissue: thyroid gland, follicular adenoma.
Validated Applications: IHC-P
Concentration: 1 mg/mL
Format: Purified
Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Magro G, Perissinotto D, Schiappacassi M, Goletz S, Otto A, Müller EC, Bisceglia M, Brown G, Ellis T, Grasso S, Colombatti A, Perris R: Proteomic and postproteomic characterization of keratan sulfate-glycanated isoforms of thyroglobulin and transferrin uniquely elaborated by papillary thyroid carcinomas. Am J Pathol. 2003 Jul163(1):183-96., URL: http://www.ncbi.nlm.nih.gov/pubmed/12819023,
Other References: *Lazar V, Bidart JM, Caillou B, Mahe C, Lacroix L, Filetti S, Schlumberger M: Expression of the Na+/I- symporter gene in human thyroid tumors: a comparison study with other thyroid-specific genes. J Clin Endocrinol Metab. 1999 Sep84(9):3228-34. , URL: https://www.ncbi.nlm.nih.gov/pubmed/10487692?dopt=,*Emerson CH, Torres MS: Recombinant human thyroid-stimulating hormone: pharmacology, clinical applications and potential uses. BioDrugs. 200317(1):19-38. Review., URL: https://www.ncbi.nlm.nih.gov/pubmed/12534318?dopt=,*Hishinuma A, Takamatsu J, Ohyama Y, Yokozawa T, Kanno Y, Kuma K, Yoshida S, Matsuura N, Ieiri T: Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter. J Clin Endocrinol Metab. 1999 Apr84(4):1438-44., URL: https://www.ncbi.nlm.nih.gov/pubmed/10199792?dopt=,
Storage Conditions: Store at 2-8°C. Do not freeze.

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