CHF-6550

• Description :

  CHF-6550 is an antagonist for muscarinic M3 receptor and an agonist for β2 adrenoceptor (MABA), with pKi of 9.3 and 10.6, respectively. CHF-6550 exhibits good hepatocyte clearance in rat models and good pharmacokinetic characteristics in guinea pigs[1].

• UNSPSC :

  12352005

• Target :

  Adrenergic Receptor; mAChR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/chf-6550.html

• Smiles :

  O=C(C1=CC=C(C=C1)CNC[C@H](O)C2=C3C=CC(NC3=C(C=C2)O)=O)NCCCOC4=CC=CC([C@](O)(C(O[C@H]5CN(CCC5)C)=O)C6=CC=CC=C6)=C4

• Molecular Formula :

  C42H46N4O8

• Molecular Weight :

  734.84

• References & Citations :

  [1]Carzaniga L, et al., Discovery, Multiparametric Optimization, and Solid-State Driven Identification of CHF-6550, a Novel Soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases. J Med Chem. 2024 Jun 10.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MAChR3; β adrenergic receptor

• CAS Number :

  [3052116-62-5]