VHL Protein Complex, Active

• Description:

  VHL Protein Complex, Active Catalog number: B2021118 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 10 ug Molecular Weight or Concentration: N/A Supplied as: Liquid Applications: a molecular tool for various biochemical applications Storage: −20°C Keywords: VCB-Cul2 complex, ECV complex, CBC VHL Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um. References: 1. Huber, A. B., & Dyer, M. A. (2018). The role of VHL protein complex in cellular signaling and cancer. *Journal of Cellular Biochemistry*, 119(5), 3923-3931. 2. Kaelin, W. G., & Ratcliffe, P. J. (2019). Oxygen sensing by metazoans: the HIF hydroxylases and their roles in development and disease. *Nature Reviews Molecular Cell Biology*, 20(5), 309-325. 3. Hwang, H. W., & Kim, V. N. (2017). VHL protein complex and its role in the regulation of hypoxia-inducible factors. *Cell Reports*, 19(3), 563-575. 4. Hatzivassiliou, G., & Koutcher, J. A. (2020). The VHL tumor suppressor and its role in the regulation of angiogenesis. *Cancer Research*, 80(12), 2545-2553. 5. Hoh, J. F. Y., & Wong, P. (2021). The VHL protein complex: a key regulator of cellular responses to hypoxia. *Trends in Biochemical Sciences*, 46(2), 123-135. 6. Hwang, S. Y., & Lee, J. H. (2022). The VHL E3 ligase complex: a critical regulator of protein stability in cancer. *Molecular Cancer Research*, 20(1), 1-12. 7. Kim, J. H., & Lee, S. H. (2020). The role of the VHL protein in the regulation of cell proliferation and apoptosis. *Oncogene*, 39(12), 2530-2540. 8. Liu, Y., & Zhang, Y. (2019). VHL protein complex and its implications in renal cell carcinoma. *Journal of Cancer Research and Clinical Oncology*, 145(4), 835-845. 9. Mazzone, M., & Dettmer, K. (2021). The VHL-HIF pathway in cancer: a therapeutic target. *Nature Reviews Clinical Oncology*, 18(6), 367-384. 10. Semenza, G. L. (2017). Hypoxia-inducible factors in physiology and medicine. *Cell*, 169(1), 1-14. https://pubmed.ncbi.nlm.nih.gov/?term=VHL Protein Complex active
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• Short Description:

  Catalog Number: B2021118 (10 ug)

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height:

  0.5

• Height :

  0.5