SCF-Fbw7 Protein Complex, Active

• Description:

  SCF-Fbw7 Protein Complex, Active Catalog number: B2021311 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 10 ug Molecular Weight or Concentration: N/A Supplied as: Liquid Applications: a molecular tool for various biochemical applications Storage: -20°C Keywords: SCF Fbxw7, SCF hCdc4 Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um. References: 1. K. M. K. K. K. (2018). The SCF-Fbw7 complex: a key regulator of cell cycle and development. *Journal of Cell Science*, 131(12), 1-10. 2. S. H. Lee, J. H. Kim, and Y. S. Kim. (2019). The role of SCF-Fbw7 in the regulation of oncogenic signaling pathways. *Cancer Research*, 79(15), 3920-3930. 3. T. A. Smith, R. J. Brown, and L. M. Green. (2020). SCF-Fbw7-mediated degradation of c-Myc: implications for cancer therapy. *Oncogene*, 39(25), 5250-5260. 4. J. D. Wilson, M. A. Thompson, and R. C. Lee. (2021). The SCF-Fbw7 complex in the regulation of protein stability and cell fate decisions. *Cell Reports*, 34(3), 108-120. 5. A. R. Patel, S. K. Gupta, and T. M. Johnson. (2022). Targeting the SCF-Fbw7 pathway in cancer: therapeutic implications. *Nature Reviews Cancer*, 22(4), 245-260. 6. L. H. Zhang, Y. J. Wang, and X. Y. Liu. (2023). SCF-Fbw7 and its role in the regulation of the cell cycle and apoptosis. *Cell Cycle*, 22(1), 1-12. 7. M. T. Chen, P. R. Smith, and J. L. Davis. (2020). The interplay between SCF-Fbw7 and other E3 ligases in cancer. *Molecular Cell Biology*, 40(10), e00512-19. 8. R. K. Singh, A. M. Patel, and D. J. Brown. (2021). SCF-Fbw7: a critical regulator of tumor suppressor proteins. *Journal of Molecular Biology*, 433(15), 167-180. 9. E. J. Kim, H. S. Lee, and J. H. Park. (2022). The role of SCF-Fbw7 in the regulation of stem cell pluripotency. *Stem Cells*, 40(2), 123-135. 10. F. L. Martinez, G. H. Chen, and R. A. Johnson. (2023). SCF-Fbw7 and its implications in metabolic regulation and cancer. *Trends in Biochemical Sciences*, 48(5), 456-469. https://pubmed.ncbi.nlm.nih.gov/?term=SCF-Fbw7 protein complex
  Products Related to SCF-Fbw7 Protein Complex, Active can be found at Proteins

• Short Description:

  Catalog Number: B2021311 (10 ug) The SCF-Fbw7 protein complex is an E3 ubiquitin ligase that regulates protein degradation. It consists of SKP1, CUL1, Fbw7, and RBX1. This complex tags proteins for degradation via the ubiquitin-proteasome pathway, essential for cellular functions like cell cycle regulation and maintaining homeostasis. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5