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(E) -PHCCC

CAT: 0804-HY-111332Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-111332Size:1 Each
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Description
(E) -PHCCC is a positive allosteric modulator (PAM) for mGluR4, that enhances the activity of the receptor's endogenous ligand (glutamate), and exhibits activity in the calcium mobilization assay in CHO cells with an EC50 of 3.2 μM[1].
CAS Number
177610-87-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/e-phccc.html
Smiles
O=C(C12C(/C(C3=CC=CC=C3O2)=N\O)([H])C1)NC4=CC=CC=C4
Molecular Formula
C17H14N2O3
Molecular Weight
294.30
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Williams R, et al., Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4. ACS Chem Neurosci. 2010 Jun 16;1 (6) :411-419.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Phccc

7-hydroxyimino-N-phenyl-1,7a-dihydrocyclopropa[b][1]benzopyran-1a-carboxamide is a 1-benzopyran.

CAS Number177610-87-6
PubChem CID5866327
IUPAC Name(7E)-7-hydroxyimino-N-phenyl-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamide
Molecular FormulaC17H14N2O3
Molecular Weight294.30
XLogP2.6
Topological Polar Surface Area70.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count22
Formal Charge0
Complexity486
SMILES
C1C\2C1(OC3=CC=CC=C3/C2=N/O)C(=O)NC4=CC=CC=C4
InChI
InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,21H,10H2,(H,18,20)/b19-15-
InChIKey
FPXPIEZPAXSELW-CYVLTUHYSA-N
Chemical Structure
2D Structure
2D structure of Phccc
CAS: 177610-87-6
CID: 5866327
Formula: C17H14N2O3
MW: 294.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight294.30
XLogP32.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass294.10044231
Monoisotopic Mass294.10044231
Topological Polar Surface Area70.9 Ų
Heavy Atom Count22
Formal Charge0
Complexity486
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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