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(E) -PHCCC

CAT: 0804-HY-111332Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-111332Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(E) -PHCCC is a positive allosteric modulator (PAM) for mGluR4, that enhances the activity of the receptor's endogenous ligand (glutamate), and exhibits activity in the calcium mobilization assay in CHO cells with an EC50 of 3.2 μM[1].
CAS Number
177610-87-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/e-phccc.html
Smiles
O=C(C12C(/C(C3=CC=CC=C3O2)=N\O)([H])C1)NC4=CC=CC=C4
Molecular Formula
C17H14N2O3
Molecular Weight
294.30
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Williams R, et al., Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4. ACS Chem Neurosci. 2010 Jun 16;1 (6) :411-419.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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