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PHCCC

CAT: 0804-HY-100409-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100409-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PHCCC is a Group I mGluR antagonist with an IC50 of 3 μM. PHCCC is a selective positive modulator of mGlu4 receptor. Antiparkinsonian effect[1][2].
CAS Number
179068-02-1
UNSPSC
12352005
Hazard Statement
H302
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PHCCC.html
Purity
99.92
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C(C12C(C2)/C(C3=CC=CC=C3O1)=N\O)NC4=CC=CC=C4
Molecular Formula
C17H14N2O3
Molecular Weight
294.31
Precautions
H302
References & Citations
[1]Marino MJ et al. Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment. Proc Natl Acad Sci U S A. 2003 Nov 11;100 (23) :13668-73.|[2]Récasens M, et al. Metabotropic glutamate receptors as drug targets. Curr Drug Targets. 2007;8 (5) :651-681.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR

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