SDU-071

• Description :

  SDU-071 is a potent and orally active inhibitor of BRD4-p53 inhibitor. SDU-071 inhibits MDA-MB-231 cells proliferation with an IC50 of 10.5 μM. SDU-071 induces cell cycle arrest and apoptosis[1].

• CAS Number :

  [3036109-10-8]

• UNSPSC :

  12352005

• Target :

  Apoptosis; Epigenetic Reader Domain

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/sdu-071.html

• Purity :

  98.75

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  COC(C=C1)=CC=C1NC2=CC(CNC3=CC=C(OC)C=C3)=NC4=C5C(C=CC=C5)=CC=C42

• Molecular Formula :

  C28H25N3O2

• Molecular Weight :

  435.52

• References & Citations :

  [1]Wang S, et al. Novel BRD4-p53 Inhibitor SDU-071 Suppresses Proliferation and Migration of MDA-MB-231 Triple-Negative Breast Cancer Cells[J]. ACS Pharmacology & Translational Science, 2024.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported