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V-11-0711

CAT: 0804-HY-120337-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120337-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
V-11-0711 is a potent and selective Chk-α (IC50 = 20 nM) inhibitor. V-11-0711 can significantly reduce PCho levels. V-11-0711 causes a reversible growth arrest. V-11-0711 induces apoptosis at high concentrations. V-11-0711 can be used for the study of cervical cancer and triple-negative breast cancer[1][2].
CAS Number
1428339-47-2
UNSPSC
12352005
Target
Apoptosis; Choline Kinase
Type
Reference compound
Related Pathways
Apoptosis; Neuronal Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/v-11-0711.html
Purity
98.54
Solubility
10 mM in DMSO
Smiles
O[C@@]([C@]1([H])C2CCN(CC2)C1)(C3=CC=CC=C3)CCC4=C(C=CC=C4)OC5CCOCC5
Molecular Formula
C27H35NO3
Molecular Weight
421.57
References & Citations
[1]Falcon SC, et al. A non-catalytic role of choline kinase alpha is important in promoting cancer cell survival. Oncogenesis. 2013;2 (3) :e38.|[2]Mori N, et al. Choline kinase-α protein and phosphatidylcholine but not phosphocholine are required for breast cancer cell survival. NMR Biomed. 2015 Dec;28 (12) :1697-706.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CHKα

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