(S,R,S)-AHPC-PEG3-NH2 (hydrochloride)

(S,R,S)-AHPC-PEG3-NH2 (hydrochloride)

• CAS Number: 2097971-11-2
• UNSPSC Description: (S,R,S)-AHPC-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/E3_ligase_Ligand-Linker_Conjugates_5.html
• Purity: 99.01
• Solubility: DMSO : 200 mg/mL (ultrasonic)
• Smiles: O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCN)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.[H]Cl
• Molecular Weight: 656.23
• References & Citations: [1]Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513.
• Shipping Conditions: Dry Ice
• Storage Conditions: -80°C, protect from light, stored under nitrogen
• Clinical Information: No Development Reported