(S,R,S)-AHPC-PEG3-NH2 (dihydrochloride)

(S,R,S)-AHPC-PEG3-NH2 (dihydrochloride)

• CAS Number: 2376990-24-6
• UNSPSC Description: (S,R,S)-AHPC-PEG3-NH2 dihydrochloride (VH032-PEG3-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology[1]
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/s-r-s-ahpc-peg3-nh2-dihydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: [H]Cl.O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(COCCOCCOCCN)=O)=O)C[C@H](O)C3.[H]Cl
• Molecular Weight: 692.69
• References & Citations: [1]Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513.|[2]Salami J, et al. Waste disposal-An attractive strategy for cancer therapy. Science. 2017;355(6330):1163-1167.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported