Gcase activator 2
CAT:
804-HY-154823-03
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Gcase activator 2
- CAS Number: 2759897-35-1
- UNSPSC Description: Gcase activator 2 (compound 14), a pyrrolo[2,3-b]pyrazine, is alos a β-Glucocerebrosidase (GCase) activator (EC50=3.8 μM). Gcase activator 2 induces GCase dimerizatio (both K-type and V-type). And Gcase activator 2 has low metabolic clearance in human and mouse[1].
- Target Antigen: Glycosidase
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Applications: Metabolism-sugar/lipid metabolism
- Field of Research: Metabolic Disease
- Assay Protocol: https://www.medchemexpress.com/gcase-activator-2.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: CC(N1CCC(C2=CC3=NC(C4=CC=C(OC)C=C4)=CN=C3N2C)CC1)=O
- Molecular Weight: 364.44
- References & Citations: [1]Benz J, et al. Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization. Angew Chem Int Ed Engl. 2021 Mar 1;60(10):5436-5442. |[2]Benz J, et al. Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization. Angew Chem Int Ed Engl. 2021 Mar 1;60(10):5436-5442.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported