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SRI-37240

CAT: 0804-HY-150089-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-150089-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses CFTR nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418[1].
CAS Number
883956-47-6
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sri-37240.html
Purity
98.29
Solubility
DMSO : 11.36 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(N(C)C(N=C(N3C4CCCCC4)C5=CC=CC=C5)=C1C3=O)C=CC=C2
Molecular Formula
C24H23N3O2
Molecular Weight
385.46
Precautions
H315, H319, H335
References & Citations
[1]Sharma J, et al. A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion. Nat Commun. 2021 Jul 16;12 (1) :4358.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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