Afegostat

• Description:

  Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1].

• Product Name Alternative:

  D-Isofagomine; Isofagomine

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H320

• Target:

  Glycosidase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Afegostat.html

• Purity:

  99.96

• Solubility:

  H2O : 4.17 mg/mL (ultrasonic)

• Smiles:

  O[C@@H]1CNC[C@H](CO)[C@H]1O

• Molecular Formula:

  C6H13NO3

• Molecular Weight:

  147.17

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]Richter F, et al. A GCase chaperone improves motor function in a mouse model of synucleinopathy. Neurotherapeutics. 2014 Oct;11 (4) :840-56.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [169105-89-9]