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Recombinant Human Interleukin-7

CAT: 0355-AP60006Size: InquireDry Ice: NoHazardous: No
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CAT#:0355-AP60006Size:Inquire
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interleukin-7 (IL-7) is encoded by the IL7 gene and secreted by stromal cells in the red marrow and thymus. It binds to the IL-7 receptor, a heterodimer consisting of IL-7 receptor alpha and IL-2 receptor gamma chain. IL-7 stimulates the differentiation of hematopoietic stem cells into lymphoid progenitor cells and also stimulates proliferation of B cells, T cells and NK cells. Murine IL-7 has approximately 65% amino acid sequence identity with human IL-7 and both proteins exhibit cross-species activity. IL-7 as an immunotherapy agent has been examined in many human clinical trials for various malignancies and during HIV infection.
Product Name Alternative
LP-1, pre-B cell factor
Gene ID
3574
UniProt
P13232
Purification
> 97% by SDS-PAGE and HPLC analyses.
Endotoxin
Less than 1 EU/ug of rHuIL-7 as determined by LAL method.
Bioactivity
8
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Calculated Molecular Weight
Approximately 17.4 kDa, a single non-glycosylated polypeptide chain containing 152 amino acids.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, 150 mM NaCl, pH 7.4.
Host or Source
Escherichia coli

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