α-Conotoxin TxID

α-Conotoxin TxID

• CAS Number: 1496617-64-1
• UNSPSC Description: α-Conotoxin TxID is a potent α3β4 nAChR antagonist with an IC50 value of 12.5 nM. α-Conotoxin TxID has weak inhibition activity of closely related α6/α3β4 nAChR (IC50= 94 nM). α-Conotoxin TxID has the potential for novel smoking cessation drug development[1].
• Target Antigen: nAChR
• Type: Peptides
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@@H](NC([C@@H](NC([C@@](CSSC[C@H](NC([C@](NC([C@@](CCC1)([H])N1C2=O)=O)([H])[C@@H](C)CC)=O)C(N)=O)([H])NC3=O)=O)CO)=O)CC4=CN=CN4)N(CCC5)[C@]5([H])C(N[C@H](C(N[C@](CSSC[C@@H]3NC(CN)=O)([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CO)=O)CCSC)=O)C)=O)CO)=O)=O)C(C)C)=O
• Molecular Weight: 1489.79
• References & Citations: [1]Xiaodan Li, et al. α-Conotoxin TxID and [S9K]TxID, α3β4 nAChR Antagonists, Attenuate Expression and Reinstatement of Nicotine-Induced Conditioned Place Preference in Mice. . Mar Drugs. 2020 Dec 16;18(12):646. doi: 10.3390/md18120646.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported