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ANS

CAT: 0804-HY-D0896-04Size: 25 gDry Ice: NoHazardous: No
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CAT#:0804-HY-D0896-04Size:25 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ANS (8-Anilino-1-naphthalenesulfonic acid) is a competitive inhibitor targeting thyroxine binding globulin (TBG) (Ki=2.09x106 M-1) . ANS is used in radioimmunoassay by displacing bound triiodothyronine (T3) to improve detection sensitivity. ANS can block the protein binding site of T3 and release free T3 for antibody recognition. As a fluorescent probe, ANS can specifically bind to the hydrophobic region of proteins (such as membrane proteins) and monitor the dynamics of protein conformation through changes in fluorescent signals. It is widely used in biochemical research and antibacterial material development[1][2].
CAS Number
82-76-8
Product Name Alternative
ANSA; 8-Anilino-1-naphthalenesulfonic acid
UNSPSC
12352200
Hazard Statement
H315, H319
Target
Bacterial
Type
Biochemical Assay Reagents
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ans.html
Purity
98.01
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(O)(C1=CC=CC2=CC=CC(NC3=CC=CC=C3)=C21)=O
Molecular Formula
C16H13NO3S
Molecular Weight
299.35
Precautions
H315, H319
References & Citations
[1]Polak J, et al. Bioactive Properties of a Novel Antibacterial Dye Obtained from Laccase-Mediated Oxidation of 8-Anilino-1-naphthalenesulfonic Acid. Molecules. 2022 Jan 13;27 (2) :487.|[2]Brown ML, et al. Use of 8-anilino-1-naphthalenesulfonic acid in radioimmunoassay of triiodothyronine. J Pharm Sci. 1974 Aug;63 (8) :1214-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Biochemical Assay Reagents
Clinical Information
Phase 4

Chemical Information

8-Anilino-1-naphthalenesulfonic acid

8-anilinonaphthalene-1-sulfonic acid is a naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8. It has a role as a fluorescent probe. It is a naphthalenesulfonic acid and an aminonaphthalene.

CAS Number82-76-8
PubChem CID1369
IUPAC Name8-anilinonaphthalene-1-sulfonic acid
Molecular FormulaC16H13NO3S
Molecular Weight299.3
XLogP3.5
Topological Polar Surface Area74.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count21
Formal Charge0
Complexity439
SMILES
C1=CC=C(C=C1)NC2=CC=CC3=C2C(=CC=C3)S(=O)(=O)O
InChI
InChI=1S/C16H13NO3S/c18-21(19,20)15-11-5-7-12-6-4-10-14(16(12)15)17-13-8-2-1-3-9-13/h1-11,17H,(H,18,19,20)
InChIKey
FWEOQOXTVHGIFQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 8-Anilino-1-naphthalenesulfonic acid
CAS: 82-76-8
CID: 1369
Formula: C16H13NO3S
MW: 299.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight299.3
XLogP33.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass299.06161445
Monoisotopic Mass299.06161445
Topological Polar Surface Area74.8 Ų
Heavy Atom Count21
Formal Charge0
Complexity439
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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