(R) -Thalidomide

CAT: 0804-HY-14658B-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-14658B-01Size:1 mg
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Description
(R) -Thalidomide ((R) - (+) -Thalidomide) is the R-enantiomer of Thalidomide. (R) -Thalidomide has psychomotor stabilizing properties[1][2].
CAS Number
[2614-06-4]
Product Name Alternative
(R) - (+) -Thalidomide
UNSPSC
12352005
Hazard Statement
H302, H360
Target
Apoptosis; Autophagy; Ligands for E3 Ligase; Molecular Glues
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/r-thalidomide.html
Purity
99.80
Solubility
DMSO : 15 mg/mL (ultrasonic; warming)
Smiles
O=C1N([C@H](CC2)C(NC2=O)=O)C(C3=C1C=CC=C3)=O
Molecular Formula
C13H10N2O4
Molecular Weight
258.23
Precautions
H302, H360
References & Citations
[1]Murphy S, et al. Enantioselectivity of thalidomide serum and tissue concentrations in a rat glioma model and effects of combination treatment with cisplatin and BCNU. J Pharm Pharmacol. 2007 Jan;59 (1) :105-14.|[2]Eriksson T, et al. Intravenous formulations of the enantiomers of thalidomide: pharmacokinetic and initial pharmacodynamic characterization in man. J Pharm Pharmacol. 2000 Jul;52 (7) :807-17.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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