β-catenin-IN-3

β-catenin-IN-3

• CAS Number: 1005288-15-2
• UNSPSC Description: β-catenin-IN-3 (compound C2) is a potent and selective β-catenin inhibitor with a KD value of 54.96 nM. β-catenin-IN-3 acts by targeting a cryptic allosteric modulation site of β-catenin. β-catenin-IN-3 can significantly reduce viability of β-catenin-driven cancer cells[1].
• Target Antigen: Wnt; β-catenin
• Type: Reference compound
• Related Pathways: Stem Cell/Wnt
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/β-catenin-in-3.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: S=C(N/C=C/C(C=C1Br)=C(C(Br)=C1)O)NC(C2)C3C(C=CC4)C4C2C3
• Molecular Weight: 484.25
• References & Citations: [1]Cheltsov A, et al. Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer. Sci Rep. 2020;10(1):8096. Published 2020 May 15.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported