Glycodeoxycholic Acid
CAT:
804-HY-125731-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Glycodeoxycholic Acid
- CAS Number: 360-65-6
- UNSPSC Description: Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis[1][2][3].
- Target Antigen: Autophagy; Endogenous Metabolite; STAT
- Type: Natural Products
- Related Pathways: Autophagy;JAK/STAT Signaling;Metabolic Enzyme/Protease;Stem Cell/Wnt
- Field of Research: Cancer; Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/glycodeoxycholic-acid.html
- Purity: 99.08
- Solubility: DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: C[C@@H]([C@]1(CC[C@]2([C@@]3(CC[C@@]4(C[C@@H](CC[C@@]4([C@]3(C[C@@H]([C@@]21C)O)[H])C)O)[H])[H])[H])[H])CCC(NCC(O)=O)=O
- Molecular Weight: 449.62
- References & Citations: [1]Shi C, et al. Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells. Aging (Albany NY). 2020 Aug 3;12(15):15546-15555.|[2]Vaz AR, et al. Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid. J Neurochem. 2010 Jan;112(1):56-65.|[3]Fauzi A, et al. Role of glycodeoxycholic acid to induce acute pancreatitis in Macaca nemestrina. J Med Primatol. 2022 Jun;51(3):134-142. doi: 10.1111/jmp.12577. Epub 2022 Mar 20. PMID: 35306662; PMCID: PMC9310849.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported