Glycodeoxycholic acid

• Description:

  Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis[1][2][3].

• UNSPSC:

  12352211

• Hazard Statement:

  H315, H319, H335

• Target:

  Autophagy; Endogenous Metabolite; STAT

• Type:

  Natural Products

• Related Pathways:

  Autophagy; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/glycodeoxycholic-acid.html

• Concentration:

  10mM

• Purity:

  99.91

• Solubility:

  DMSO : 87.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  C[C@@H]([C@]1(CC[C@]2([C@@]3(CC[C@@]4(C[C@@H](CC[C@@]4([C@]3(C[C@@H]([C@@]21C)O)[H])C)O)[H])[H])[H])[H])CCC(NCC(O)=O)=O

• Molecular Formula:

  C26H43NO5

• Molecular Weight:

  449.62

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Shi C, et al. Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells. Aging (Albany NY) . 2020 Aug 3;12 (15) :15546-15555.|[2]Vaz AR, et al. Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid. J Neurochem. 2010 Jan;112 (1) :56-65.|[3]Fauzi A, et al. Role of glycodeoxycholic acid to induce acute pancreatitis in Macaca nemestrina. J Med Primatol. 2022 Jun;51 (3) :134-142. doi: 10.1111/jmp.12577. Epub 2022 Mar 20. PMID: 35306662; PMCID: PMC9310849.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [360-65-6]