Glycodeoxycholic acid

CAT: 0804-HY-125731-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-125731-01Size:100 mg
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Description
Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis[1][2][3].
CAS Number
[360-65-6]
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Autophagy; Endogenous Metabolite; STAT
Type
Natural Products
Related Pathways
Autophagy; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/glycodeoxycholic-acid.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 87.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@@H]([C@]1(CC[C@]2([C@@]3(CC[C@@]4(C[C@@H](CC[C@@]4([C@]3(C[C@@H]([C@@]21C)O)[H])C)O)[H])[H])[H])[H])CCC(NCC(O)=O)=O
Molecular Formula
C26H43NO5
Molecular Weight
449.62
Precautions
H315, H319, H335
References & Citations
[1]Shi C, et al. Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells. Aging (Albany NY) . 2020 Aug 3;12 (15) :15546-15555.|[2]Vaz AR, et al. Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid. J Neurochem. 2010 Jan;112 (1) :56-65.|[3]Fauzi A, et al. Role of glycodeoxycholic acid to induce acute pancreatitis in Macaca nemestrina. J Med Primatol. 2022 Jun;51 (3) :134-142. doi: 10.1111/jmp.12577. Epub 2022 Mar 20. PMID: 35306662; PMCID: PMC9310849.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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