Glycodeoxycholic acid-d5

Glycodeoxycholic acid-d5

• UNSPSC Description: Glycodeoxycholic acid-d5 is deuterium labeled Glycodeoxycholic Acid. Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis[1][2][3][4].
• Target Antigen: Autophagy; Endogenous Metabolite; Isotope-Labeled Compounds; STAT
• Type: Isotope-Labeled Compounds
• Related Pathways: Autophagy;JAK/STAT Signaling;Metabolic Enzyme/Protease;Others;Stem Cell/Wnt
• Field of Research: Inflammation/Immunology
• Smiles: [H][C@@]12C([2H])([C@@]([2H])(C([2H])(C[C@@]1([C@H](C3CC2)C[C@H]([C@]4([C@]3(CC[C@@H]4[C@@H](CCC(NCC(O)=O)=O)C)[H])C)O)C)[2H])O)[2H]
• Molecular Weight: 454.65
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Shi C, et al. Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells. Aging (Albany NY). 2020 Aug 3;12(15):15546-15555.|[3]Vaz AR, et al. Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid. J Neurochem. 2010 Jan;112(1):56-65.|[4]Fauzi A, et al. Role of glycodeoxycholic acid to induce acute pancreatitis in Macaca nemestrina. J Med Primatol. 2022 Jun;51(3):134-142. doi: 10.1111/jmp.12577. Epub 2022 Mar 20. PMID: 35306662; PMCID: PMC9310849.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported