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Glycodeoxycholic acid-d5

CAT: 0804-HY-W653999Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W653999Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glycodeoxycholic acid-d5 is deuterium labeled Glycodeoxycholic Acid. Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis[1][2][3][4].
UNSPSC
12352211
Target
Autophagy; Endogenous Metabolite; Isotope-Labeled Compounds; STAT
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; JAK/STAT Signaling; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
[H][C@@]12C([2H])([C@@]([2H])(C([2H])(C[C@@]1([C@H](C3CC2)C[C@H]([C@]4([C@]3(CC[C@@H]4[C@@H](CCC(NCC(O)=O)=O)C)[H])C)O)C)[2H])O)[2H]
Molecular Formula
C26H38D5NO5
Molecular Weight
454.65
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Shi C, et al. Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells. Aging (Albany NY) . 2020 Aug 3;12 (15) :15546-15555.|[3]Vaz AR, et al. Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid. J Neurochem. 2010 Jan;112 (1) :56-65.|[4]Fauzi A, et al. Role of glycodeoxycholic acid to induce acute pancreatitis in Macaca nemestrina. J Med Primatol. 2022 Jun;51 (3) :134-142. doi: 10.1111/jmp.12577. Epub 2022 Mar 20. PMID: 35306662; PMCID: PMC9310849.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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