DMPO

• UNSPSC Description:

  DMPO is a cell permeable hydrophillic spin trap agent for superoxide detection[1].

• Target Antigen:

  NO Synthase; Reactive Oxygen Species

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/dmpo.html

• Purity:

  99.90

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 100 mg/mL

• Smiles:

  CC1(C)[N+]([O-])=CCC1

• Molecular Weight:

  113.16

• References & Citations:

  [1]Ranguelova K, Mason RP. The fidelity of spin trapping with DMPO in biological systems. Magn Reson Chem. 2011;49(4):152-158. |[2]Konaka R, Kawai M, Noda H, Kohno M, Niwa R. Synthesis and evaluation of DMPO-type spin traps. Free Radic Res. 1995;23(1):15-25. |[3]Das A, et al. Reversal of SIN-1-induced eNOS dysfunction by the spin trap, DMPO, in bovine aortic endothelial cells via eNOS phosphorylation. Br J Pharmacol. 2014 May;171(9):2321-34.|[4]Britigan BE, Hamill DR. Effect of the spin trap 5,5 dimethyl-1-pyrroline-N-oxide (DMPO) on human neutrophil function: novel inhibition of neutrophil stimulus-response coupling? Free Radic Biol Med. 1990;8(5):459-70. |[5]Zhai Z, et al. The spin trap 5,5-dimethyl-1-pyrroline N-oxide inhibits lipopolysaccharide-induced inflammatory response in RAW 264.7 cells. Life Sci. 2012 Mar 10;90(11-12):432-9.|[6]Woo suk Chung, et al. Antinociceptive Effect of Intraperitoneally Administered 5,5-dimethyl-1-pyrroline N-oxide on Formalin Induced Nociception in Rats. Korean Journal of Anesthesiology 2008;54(3):S35-S39.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  No Development Reported

• CAS Number:

  3317-61-1