SU-11752

• UNSPSC Description:

  SU-11752 is an inhibitor for DNA-dependent protein kinase (DNA-PK) with an IC50 of 0.13 μM. SU-11752 inhibits PI3K p110γ kinase with IC50 of 1.1 μM. SU-11752 binds competitively for ATP-site in DNA-PK, results in inhibition of intracellular DNA double-strand break repair and increases the sensitivity of cells to radiotherapy[1].

• Target Antigen:

  DNA-PK; PI3K

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/su-11752.html

• Smiles:

  O=C(CCC1=C(NC(/C=C2C(NC3=C\2C=C(C=C3)S(=O)(NC4=CC=CC=C4)=O)=O)=C1CC)CC)O

• Molecular Weight:

  493.57

• References & Citations:

  [1]Ismail IH, et al., SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization. Oncogene. 2004 Jan 29;23(4):873-82.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  688036-19-3