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SU 5402 (GMP)

CAT: 0804-HY-10407GSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-10407GSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SU 5402 (GMP) is SU 5402 produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGFRβ, respectively[1].
CAS Number
215543-92-3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
EGFR; PDGFR; VEGFR
Type
GMP Small Molecules
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/su-5402-gmp.html
Solubility
10 mM in DMSO
Smiles
O=C(CCC1=C(NC=C1C)/C=C2C(NC3=C\2C=CC=C3)=O)O
Molecular Formula
C17H16N2O3
Molecular Weight
296.32
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Zeng H, et al. Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells. PLoS One. 2010 Jul 29;5 (7) :e11853. |[2]Nishihara K, et al. Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression. Stem Cell Reports. 2019 Feb 12;12 (2) :305-318. |[3]Ito A, et al. Efficient and robust induction of retinal pigment epithelium cells by tankyrase inhibition regardless of the differentiation propensity of human induced pluripotent stem cells. Biochem Biophys Res Commun. 2021 May 7;552:66-72. |[4]Chambers SM, et al. Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nat Biotechnol. 2012 Jul 1;30 (7) :715-20.
Shipping Conditions
Room temperature
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; PDGFRβ; VEGFR2/KDR/Flk-1

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