SU-4313

• Description :

  SU-4313 is a potent protein tyrosine kinases (PTKs) modulator with IC50s of 14.5 μM, 18.8 μM, 11 μM, 16.9 μM, 8.0 μM for PDGFR, FLK-1, EGFR, HER2 Kinase and IGF-1R, respectively. SU-4313 has the potential for modulating tyrosine kinase signal transduction in order to regulate abnormal cell proliferation[1].

• CAS Number :

  [186611-55-2]

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319

• Target :

  EGFR; IGF-1R; PDGFR

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/su-4313.html

• Purity :

  99.31

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1NC2=C(/C1=C/C3=CC=C(C(C)C)C=C3)C=CC=C2

• Molecular Formula :

  C18H17NO

• Molecular Weight :

  263.33

• Precautions :

  H315, H319

• References & Citations :

  [1]Peng Cho Tang, et al. Indolinone compounds for the treatment of disease. WO1996040116A1.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  EGFR/ErbB1/HER1; ErbB2/HER2; PDGFR