Phenformin
CAT:
804-HY-16397-02
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No

Phenformin
- CAS Number: 114-86-3
- UNSPSC Description: Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis[1][2].
- Target Antigen: AMPK; Apoptosis; Mitochondrial Metabolism
- Type: Reference compound
- Related Pathways: Apoptosis;Epigenetics;Metabolic Enzyme/Protease;PI3K/Akt/mTOR
- Applications: Metabolism-sugar/lipid metabolism
- Field of Research: Cancer; Metabolic Disease
- Assay Protocol: https://www.medchemexpress.com/phenformin.html
- Solubility: H2O : 350 mg/mL (ultrasonic)
- Smiles: NC(NC(NCCC1=CC=CC=C1)=N)=N
- Molecular Weight: 205.26
- References & Citations: [1]García Rubiño ME, et al. Phenformin as an Anticancer Agent: Challenges and Prospects. Int J Mol Sci. 2019 Jul 5;20(13):3316.|[2]Yendapally R, et al. A review of phenformin, metformin, and imeglimin. Drug Dev Res. 2020 Jun;81(4):390-401.
- Shipping Conditions: Room Temperature
- Clinical Information: Launched