Phenformin

• UNSPSC Description:

  Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis[1][2].

• Target Antigen:

  AMPK; Apoptosis; Mitochondrial Metabolism

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Epigenetics;Metabolic Enzyme/Protease;PI3K/Akt/mTOR

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Cancer; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/phenformin.html

• Solubility:

  H2O : 350 mg/mL (ultrasonic)

• Smiles:

  NC(NC(NCCC1=CC=CC=C1)=N)=N

• Molecular Weight:

  205.26

• References & Citations:

  [1]García Rubiño ME, et al. Phenformin as an Anticancer Agent: Challenges and Prospects. Int J Mol Sci. 2019 Jul 5;20(13):3316.|[2]Yendapally R, et al. A review of phenformin, metformin, and imeglimin. Drug Dev Res. 2020 Jun;81(4):390-401.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Launched

• CAS Number:

  114-86-3