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PH-Low Insertion Peptide

CAT: 0804-HY-P4116-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P4116-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PH-Low Insertion Peptide (pHLIP) is a short, pH-responsive peptide capable of inserting across a cell membrane to form a transmembrane helix at acidic pH. pH-Low Insertion Peptide targets the acidic tumor microenvironment for tumors at early and metastatic stages with high specificity, used as a specific ligand. pH-Low Insertion Peptide successfully modify polylysine polymers to have the pH-responsive capability. pH-Low Insertion Peptide-based targeting of cancer presents an opportunity to monitor metabolic changes, and to selectively deliver imaging and therapeutic agents to tumors[1][2][3].
CAS Number
2293160-09-3
Product Name Alternative
PHLIP
UNSPSC
12352209
Target
Others
Type
Peptides
Related Pathways
Others
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ph-low-insertion-peptide.html
Purity
98.35
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[Ala-Cys-Glu-Gln-Asn-Pro-Ile-Tyr-Trp-Ala-Arg-Tyr-Ala-Asp-Trp-Leu-Phe-Thr-Thr-Pro-Leu-Leu-Leu-Leu-Asp-Leu-Ala-Leu-Leu-Val-Asp-Ala-Asp-Glu-Thr]
Molecular Formula
C189H282N42O55S
Molecular Weight
4054.56
References & Citations
[1]Yushuang Wei, et al. pH-responsive pHLIP (pH low insertion peptide) nanoclusters of superparamagnetic iron oxide nanoparticles as a tumor-selective MRI contrast agent. Acta Biomater. 2017 Jun;55:194-203.|[2]Adochite RC, et al. Targeting breast tumors with pH (low) insertion peptides[J]. Mol Pharm. 2014 Aug 4;11 (8) :2896-905.|[3]Svoronos AA, et al. Tumor-Targeted, Cytoplasmic Delivery of Large, Polar Molecules Using a pH-Low Insertion Peptide[J]. Mol Pharm. 2020 Feb 3;17 (2) :461-471.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported

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