Ph-HTBA

• Description :

  Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders[1].

• UNSPSC :

  12352005

• Target :

  CaMK

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ph-htba.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O)/C=C1CCCC2=CC(C3=CC=CC=C3)=CC=C2C\1O

• Molecular Formula :

  C19H18O3

• Molecular Weight :

  294.34

• References & Citations :

  [1]Yongsong Tian, et al. Exploring the NCS-382 Scaffold for CaMKIIα Modulation: Synthesis, Biochemical Pharmacology, and Biophysical Characterization of Ph-HTBA as a Novel High-Affinity Brain-Penetrant Stabilizer of the CaMKIIα Hub Domain. J Med Chem. 2022 Nov 8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2368927-41-5]