Ph-HTBA

CAT: 0804-HY-151797Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-151797Size:1 Each
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Description
Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders[1].
CAS Number
[2368927-41-5]
UNSPSC
12352005
Target
CaMK
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ph-htba.html
Solubility
10 mM in DMSO
Smiles
O=C(O)/C=C1CCCC2=CC(C3=CC=CC=C3)=CC=C2C\1O
Molecular Formula
C19H18O3
Molecular Weight
294.34
References & Citations
[1]Yongsong Tian, et al. Exploring the NCS-382 Scaffold for CaMKIIα Modulation: Synthesis, Biochemical Pharmacology, and Biophysical Characterization of Ph-HTBA as a Novel High-Affinity Brain-Penetrant Stabilizer of the CaMKIIα Hub Domain. J Med Chem. 2022 Nov 8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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