Ph-HTBA

• UNSPSC Description:

  Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders[1].

• Target Antigen:

  CaMK

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ph-htba.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)/C=C1CCCC2=CC(C3=CC=CC=C3)=CC=C2C\1O

• Molecular Weight:

  294.34

• References & Citations:

  [1]Yongsong Tian,et al. Exploring the NCS-382 Scaffold for CaMKIIα Modulation: Synthesis, Biochemical Pharmacology, and Biophysical Characterization of Ph-HTBA as a Novel High-Affinity Brain-Penetrant Stabilizer of the CaMKIIα Hub Domain. J Med Chem. 2022 Nov 8.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2368927-41-5