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PDpep1.3

CAT: 0804-HY-P10404Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P10404Size:1 Each
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Description
PDpep1.3 is a peptide inhibitor of α-synuclein that disrupts the direct interaction between α-synuclein and CHarged Multivesicular body Protein 2B (CHMP2B) . As a result, PDpep1.3 restores the degradation function of endosomes and lysosomes, reduces the protein level and aggregation of α-synuclei, and protects dopaminergic neurons from α-synuclei-mediated degeneration. PDpep1.3 can be used to study neurodegenerative diseases and protein-protein interactions[1].
CAS Number
2942277-55-4
UNSPSC
12352209
Target
α-synuclein
Type
Peptides
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Others
Assay Protocol
https://www.medchemexpress.com/pdpep1-3.html
Smiles
O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N
Molecular Formula
C59H101N17O22
Molecular Weight
1400.53
References & Citations
[1]Nim S, et al. Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson’s disease[J]. Nature Communications, 2023, 14 (1) : 2150.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
α-synuclein Aggregation; α-synuclein/CHMP2B

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