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Bethanidine (sulfate)

CAT: 0804-HY-16094Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-16094Size:1 Each
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Description
Bethanidine sulfate and its ortho-chloro derivative (BW 392C60) are potent adrenergic neurone blockers with sympathomimetic effects similar to bretylium and guanethidine in various animal models, particularly in cats. They inhibit the release of noradrenaline during nerve stimulation and enhance smooth muscle responses to adrenaline and noradrenaline. Bethanidine sulfate increases pressor responses to tyramine, though this effect diminishes with higher doses. Unlike guanethidine, Bethanidine sulfate does not deplete pressor amine content in the iris of cats post-administration. It also briefly inhibits autonomic cholinergic mechanisms and causes temporary neuromuscular paralysis in large doses, contrasting with its prolonged adrenergic neurone blocking effects[1].
CAS Number
114-85-2
Product Name Alternative
BW 467C60
UNSPSC
12352211
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bethanidine-sulfate.html
Smiles
O=S(O)(O)=O.CN/C(NC)=N/CC1=CC=CC=C1.[0.5]
Molecular Formula
C10H17N3O4S
Molecular Weight
275.32
References & Citations
[1]ADRENERGIC NEURONE BLOCKADE AND OTHER ACUTE EFFECTS CAUSED BY N-BENZYL-N′N″-DIMETHYLGUANIDINE* AND ITS ORTHO-CHLORO DERIVATIVE
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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