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IKBKG antibody

CAT: 0710-FNab10254Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab10254Size:100 µg
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Background
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.
Synonyms
NF-kappa-B essential modulator (NEMO) |FIP-3|IkB kinase-associated protein 1 (IKKAP1) |Inhibitor of nuclear factor kappa-B kinase subunit gamma (I-kappa-B kinase subunit gamma, IKK-gamma, IKKG, IkB kinase subunit gamma) |NF-kappa-B essential modifier|IKBKG|FIP3|NEMO
Gene ID
8517
UniProt
Q9Y6K9
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Target
IKBKG
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Immunology, Cardiovascular, Metabolism, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
40-55 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
183-339aa

UniProtKB · Q9Y6K9

NF-kappa-B essential modulator

NEMO_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y6K9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IKBKG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
NEMO
EC number
—
Processing
—
Secondary accessions
Q7LBY6, Q7Z7F1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Domain

Coiled coilZinc-finger

Cellular component

CytoplasmNucleus

Disease

Disease variantEctodermal dysplasiaOsteopetrosis

PTM

Disulfide bondIsopeptide bondPhosphoproteinUbl conjugation

Biological process

DNA damageHost-virus interactionTranscriptionTranscription regulation

Ligand

Metal-bindingZinc

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