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ZBP1 antibody

CAT: 0710-FNab09586Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09586Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity) .
Synonyms
Z-DNA-binding protein 1|DNA-dependent activator of IFN-regulatory factors (DAI) |Tumor stroma and activated macrophage protein DLM-1|ZBP1|C20orf183|DLM1
Gene ID
81030
UniProt
Q9H171
Host
Rabbit
Reactivity
Human
Immunogen
Z-DNA binding protein 1
Target
ZBP1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
66 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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