CCN4 antibody

• Background:

  Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.

• Synonyms:

  CCN family member 4|WNT1-inducible-signaling pathway protein 1 (WISP-1)|Wnt-1-induced secreted protein|CCN4|WISP1

• Gene ID:

  8840

• UniProt:

  O95388

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  WNT1 inducible signaling pathway protein 1

• Target:

  CCN4

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, IHC, WB

• Field of Research:

  Immunology, Cancer, Stem Cells

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:200-1:2000; IHC: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  45 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

• CAS Number:

  9007-83-4