CCN4 antibody

• Background :

  Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X (L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.

• Synonyms :

  CCN family member 4|WNT1-inducible-signaling pathway protein 1 (WISP-1) |Wnt-1-induced secreted protein|CCN4|WISP1

• Gene ID :

  8840

• UniProt :

  O95388

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  WNT1 inducible signaling pathway protein 1

• Target :

  CCN4

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, IHC, WB

• Field of Research :

  Immunology, Cancer, Stem Cells

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:200-1:2000; IHC: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  45 kDa

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, IHC, WB