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VPS26A antibody

CAT: 0710-FNab09432Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09432Size:100 µg
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Background
Acts as component of the retromer cargo-selective complex (CSC) . The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable) . The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable) . Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903) . Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922) . Required for the endosomal localization of FAM21A (indicative for the WASH complex) (PubMed:22070227) . Required for the endosomal localization of TBC1D5 (PubMed:20923837) . Mediates retromer cargo reognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231) . Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403) . Involved in recycling of ADRB2 (PubMed:21602791) . Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity) .
Synonyms
Vacuolar protein sorting-associated protein 26A|Vesicle protein sorting 26A (hVPS26) |VPS26A|VPS26
Gene ID
9559
UniProt
O75436
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Vacuolar protein sorting 26 homolog A
Target
VPS26A
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC,IF
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
38 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

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