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FLT1 antibody

CAT: 0710-FNab09393Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09393Size:100 µg
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Background
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig) -like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
Synonyms
Vascular endothelial growth factor receptor 1 (VEGFR-1) |Fms-like tyrosine kinase 1 (FLT-1) |Tyrosine-protein kinase FRT|Tyrosine-protein kinase receptor FLT (FLT) |Vascular permeability factor receptor|FLT1|FLT|FRT|VEGFR1
Gene ID
2321
UniProt
P17948
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
Target
FLT1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
151 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
1mg/ml

UniProtKB · P17948

Vascular endothelial growth factor receptor 1

VGFR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P17948
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FLT1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
VEGFR-1
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
A3E342, A3E344, A8KA71, B0LPF1, B2BF46, B2BF47, B2BF48, B3FR89, B5A923, F5H5L6, O60722, P16057, Q12954
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

AngiogenesisChemotaxisDifferentiation

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCytoplasmEndosomeMembraneSecreted

Molecular function

Developmental proteinKinaseReceptorTransferaseTyrosine-protein kinase

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

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