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FLT3 antibody

CAT: 0710-FNab03164Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab03164Size:100 µg
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Background
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
Synonyms
Receptor-type tyrosine-protein kinase FLT3|FL cytokine receptor|Fetal liver kinase-2 (FLK-2) |Fms-like tyrosine kinase 3 (FLT-3) |Stem cell tyrosine kinase 1 (STK-1) |FLT3|CD135|FLK2|STK1
Gene ID
2322
UniProt
P36888
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Fms-related tyrosine kinase 3
Target
FLT3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP
Field of Research
Stem Cells, Immunology, Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
130-140 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP

UniProtKB · P36888

Receptor-type tyrosine-protein kinase FLT3

FLT3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P36888
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FLT3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
A0AVG9, B7ZLT7, B7ZLT8, F5H0A0, Q13414
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Disease

Disease variantProto-oncogene

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Cellular component

Endoplasmic reticulumMembrane

Biological process

Host-virus interaction

Domain

Immunoglobulin domainSignalTransmembraneTransmembrane helix

Molecular function

KinaseReceptorTransferaseTyrosine-protein kinase

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