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TNFSF12 antibody

CAT: 0710-FNab08827Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08827Size:100 µg
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Background
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
Synonyms
Tumor necrosis factor ligand superfamily member 12|APO3 ligand|TNF-related weak inducer of apoptosis (TWEAK) |Tumor necrosis factor ligand superfamily member 12, membrane form|Tumor necrosis factor ligand superfamily member 12, secreted form|TNFSF12|APO3L|DR3LG
Gene ID
8742
UniProt
O43508
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Tumor necrosis factor (ligand) superfamily, member 12
Target
TNFSF12
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Immunology, Signal Transduction, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
25 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · O43508

Tumor necrosis factor ligand superfamily member 12

TNF12_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43508
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNFSF12
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q8IZK7, Q8WUZ7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

AngiogenesisApoptosisDifferentiation

Cellular component

Cell membraneMembraneSecreted

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoprotein

Molecular function

CytokineDevelopmental protein

Domain

Signal-anchorTransmembraneTransmembrane helix

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