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TNFSF11 antibody

CAT: 0710-FNab07108Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07108Size:100 µg
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Background
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Synonyms
Tumor necrosis factor ligand superfamily member 11|Osteoclast differentiation factor (ODF) |Osteoprotegerin ligand (OPGL) |Receptor activator of nuclear factor kappa-B ligand (RANKL) |TNF-related activation-induced cytokine (TRANCE) |Tumor necrosis factor ligand superfamily member 11, membrane form|Tumor necrosis factor ligand superfamily member 11, soluble form|TNFSF11|OPGL|RANKL|TRANCE
Gene ID
8600
UniProt
O14788
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Tumor necrosis factor (ligand) superfamily, member 11
Target
TNFSF11
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Immunology, Signal Transduction, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
32 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

UniProtKB · O14788

Tumor necrosis factor ligand superfamily member 11

TNF11_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O14788
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNFSF11
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TNFSF11
EC number
—
Processing
—
Secondary accessions
O14723, Q96Q17, Q9P2Q3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCytoplasmMembraneSecreted

Molecular function

CytokineDevelopmental proteinReceptor

Biological process

Differentiation

Disease

Disease variantOsteopetrosis

PTM

Glycoprotein

Domain

Signal-anchorTransmembraneTransmembrane helix

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