TFE3 antibody

• Background :

  Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3') . Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4 (+) T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site.

• Synonyms :

  Transcription factor E3|Class E basic helix-loop-helix protein 33 (bHLHe33) |TFE3|BHLHE33

• Gene ID :

  7030

• UniProt :

  P19532

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Transcription factor binding to IGHM enhancer 3

• Target :

  TFE3

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IP,IHC

• Field of Research :

  Cancer, Immunology, Metabolism

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:50-1:500

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  65 kDa

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IP, IHC

• Immunogen Sequence :

  1-300aa