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TDP1 antibody

CAT: 0710-FNab08572Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08572Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.
Synonyms
Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) |TDP1
Gene ID
55775
UniProt
Q9NUW8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Tyrosyl-DNA phosphodiesterase 1
Target
TDP1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP
Field of Research
Neuroscience, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
68 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP

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