TCTN1 antibody

TCTN1 antibody

• Background: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog(Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23(By similarity).
• Synonyms: Tectonic-1|TCTN1|TECT1
• CAS Number: 9007-83-4
• Gene ID: 79600
• UniProt: Q2MV58
• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Immunogen: tectonic family member 1
• Target: TCTN1
• Clonality: Polyclonal
• Isotype: IgG
• Applications: ELISA, WB, IF, IHC
• Field of Research: Developmental biology
• Purification: Immunogen affinity purified
• Dilution: WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
• Purity: ≥95% as determined by SDS-PAGE
• Form: Liquid
• Molecular Weight: 55-64 kDa
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)