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SMAD7 antibody

CAT: 0710-FNab07999Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07999Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity) .
Synonyms
Mothers against decapentaplegic homolog 7 (MAD homolog 7, Mothers against DPP homolog 7) |Mothers against decapentaplegic homolog 8 (MAD homolog 8, Mothers against DPP homolog 8) |SMAD family member 7 (SMAD 7, Smad7, hSMAD7) |SMAD7|MADH7|MADH8
Gene ID
4092
UniProt
O15105
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
SMAD family member 7
Target
SMAD7
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Cancer, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
46 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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