SMAD7 antibody

• Background:

  Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity) .

• Synonyms:

  Mothers against decapentaplegic homolog 7 (MAD homolog 7, Mothers against DPP homolog 7) |Mothers against decapentaplegic homolog 8 (MAD homolog 8, Mothers against DPP homolog 8) |SMAD family member 7 (SMAD 7, Smad7, hSMAD7) |SMAD7|MADH7|MADH8

• Gene ID:

  4092

• UniProt:

  O15105

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  SMAD family member 7

• Target:

  SMAD7

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB

• Field of Research:

  Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Cancer, Developmental biology

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  46 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB