SMAD1 antibody

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SMAD1 antibody

CAT:

710-FNab07992

Size:

100 µg

Price:

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For price, please contact [email protected].

Background: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
Synonyms: Mothers against decapentaplegic homolog 1 (MAD homolog 1, Mothers against DPP homolog 1)|JV4-1|Mad-related protein 1|SMAD family member 1 (SMAD 1, Smad1, hSMAD1)|Transforming growth factor-beta-signaling protein 1 (BSP-1)|SMAD1|BSP1|MADH1|MADR1
Gene ID: 4086
UniProt: Q15797
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: SMAD family member 1
Target: SMAD1
Clonality: Polyclonal
Isotype: IgG
Applications: ELISA, WB, IHC, IF
Field of Research: Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Cancer, Developmental biology, Stem Cells
Purification: Immunogen affinity purified
Dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular Weight: 54 kDa
Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Complementary Product Range

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FNab07992	SMAD1 antibody
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