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SMAD1 antibody

CAT: 0710-FNab07992Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07992Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
Synonyms
Mothers against decapentaplegic homolog 1 (MAD homolog 1, Mothers against DPP homolog 1) |JV4-1|Mad-related protein 1|SMAD family member 1 (SMAD 1, Smad1, hSMAD1) |Transforming growth factor-beta-signaling protein 1 (BSP-1) |SMAD1|BSP1|MADH1|MADR1
Gene ID
4086
UniProt
Q15797
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
SMAD family member 1
Target
SMAD1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Cancer, Developmental biology, Stem Cells
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
54 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

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