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SIRT1 antibody

CAT: 0710-FNab07878Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07878Size:100 µg
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Background
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
Synonyms
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) |NAD-dependent protein deacylase sirtuin-1|Regulatory protein SIR2 homolog 1|SIR2-like protein 1 (hSIR2) |SirtT1 75 kDa fragment (75SirT1) |SIRT1|SIR2L1
Gene ID
23411
UniProt
Q96EB6
Host
Mouse
Reactivity
Human
Immunogen
Sirtuin (silent mating type information regulation 2 homolog) 1
Target
SIRT1
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IHC, IP
Field of Research
Neuroscience, Stem Cells, Metabolism, Developmental biology
Purification
Protein A+G purification
Dilution
WB: 1:2000-1:5000; IP: 1:500-1:2000 for WB; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
130 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
6A1
Tested Applications
ELISA, WB, IHC, IP
Immunogen Sequence
1-350aa

UniProtKB · Q96EB6

NAD-dependent protein deacetylase sirtuin-1

SIR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96EB6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SIRT1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
hSIRT1
EC number
2.3.1.286
Processing
—
Secondary accessions
Q2XNF6, Q5JVQ0, Q9GZR9, Q9Y6F0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationMethylationPhosphoproteinS-nitrosylationUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisBiological rhythmsDifferentiationHost-virus interactionMyogenesisTranscriptionTranscription regulation

Cellular component

CytoplasmMitochondrionNucleus

Molecular function

Developmental proteinTransferase

Ligand

Metal-bindingNADZinc

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